According to the findings, while more cases in the modafinil group (n = 14) showed a positive response in some of the subscales of SANS, in comparison with the placebo group (n = 6; P < 0.04), the intractability of the deficit syndrome of schizophrenia against augmentative modafinil was obvious because there was no significant decrease in the mean total score of SANS in the target group in comparison with the placebo group at the end of the assessment (P < 0.08).

2021-03-04 · The presence of metabolic disorders appeared significantly linked to cognitive deficits among individuals with schizophrenia, according to results of a systematic review and meta-analysis

According to the findings, while more cases in the modafinil group (n = 14) showed a positive response in some of the subscales of SANS, in comparison with the placebo group (n = 6; P < 0.04), the intractability of the deficit syndrome of schizophrenia against augmentative modafinil was obvious because there was no significant decrease in the mean total score of SANS in the target group in comparison with the … Negative symptoms in schizophrenia include: 1) Restricted up to flat affect 2) Apathy 3) Alogia 4) Anhedonia 5) Avolition 6) Asociality [1,2]. In DSM-5, negative symptoms in addition to one of the core positive symptoms (delusion, hallucination, disorganized speech) for duration of at least one month is enough for diagnosis of acute phase of schizophrenia. 2000-03-01 Associations were found between the deficit syndrome and both summer birth and a family history of schizophrenia. In contrast, nondeficit schizophrenia was associated with a family history of psychiatric problems other than schizophrenia. The deficit group also had poorer insight. The relationship between deficit syndrome and impairment in olfaction, social cognition, verbal fluency, and speed-based cognitive tasks were relatively stronger. Conclusions: Our findings suggest that there is consistent evidence for a significant relationship between deficit syndrome and more severe cognitive impairment in schizophrenia.

1998-02-09 Request PDF | Deficit syndrome in schizophrenia | From the earliest description of schizophrenia, amotivational syndrome associated with severe functional impairment is recognised. These symptoms Amelioration of deficit syndrome of schizophrenia by norepinephrine reuptake inhibitor Show all authors. Saeed Shoja Shafti. Saeed Shoja Shafti.

Asperger syndrome and schizophrenia Psychiatric and social cognitive aspects Tove Lugnegård Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden ABSTRACT Background: Asperger syndrome (AS) and schizophrenia are psychiatric disorders often implying Do you Believe That There is a Core Deficit Syndrome Subtype of Schizophrenia?– Dr. Dark, Prof Castle & Prof Pai. Posted on : October 7, 2020.

Ett subsyndromalt blandtillstånd kan innebära en funktionsinskränkning som är i of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic (2009) Common genetic determinants of schizophrenia and bipolar disorder in

non-deficit syndrome has gained increasing attention, since it proved to be a promising model from both a heuristic and clinical perspective (Carpenter et al. 1988; Kirkpatrick et al. 1989).

The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of the deficit syndrome (DS). 2 Studies comparing differences between a DS group and a non-deficit group have contributed to the hypothesis that deficit schizophrenia could be a separate disease. 7,8,9,10 However, despite evidence suggesting

Schizophrenia is a type of mental disorder characterized by several types of symptoms, including positive symptoms like delusions and Among patients with schizophrenia, presence or absence of the deficit syndrome has been suggested as a method for defining relatively homogeneous groups. The criteria for the deficit syndrome require the presence of negative symptoms that are judged primary to the illness, rather than to factors, such as depressive mood, that may resemble the negative symptoms of schizophrenia. Dutch schizophrenia patients that was enriched for deficit schizophrenia (over 50% of patients). Materials and methods Sample collection To enrich the sample for patients with the deficit syndrome, 308 schizophrenia patients were mainly recruited from psy-chiatric hospitals. Patients had at least three Dutch-born Caucasian grandparents. These findings also support the hypothesis that deficit schizophrenia is a separate disease within the schizophrenia syndrome.

This is considered a distinct tive syndrome of schizophrenia have been inconsistent. The "deficit syndrome," a reconceptualization of the negative syndrome, was developed in part to address this inconsistency. RESULTS: The deficit syndrome group had higher negative and positive scores compared to the non-deficit group.
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2000-03-01 · The deficit syndrome is a disproportionate cause of impairment in schizophrenia (Fenton and McGlashan 1994; Kirkpatrick et al. 1996a,c) and the development of effective treatments for deficit According to the findings, while more cases in the modafinil group (n = 14) showed a positive response in some of the subscales of SANS, in comparison with the placebo group (n = 6; P < 0.04), the intractability of the deficit syndrome of schizophrenia against augmentative modafinil was obvious because there was no significant decrease in the mean total score of SANS in the target group in comparison with the placebo group at the end of the assessment (P < 0.08). deficit syndrome of schizophrenia Negative symptoms of schizophrenia that persist or are found even during psychotic remissions. Such symptoms include social withdrawal, loss of motivation, poverty of speech, and blunting of affect.

Dutch schizophrenia patients that was enriched for deficit schizophrenia (over 50% of patients). Materials and methods Sample collection To enrich the sample for patients with the deficit syndrome, 308 schizophrenia patients were mainly recruited from psy-chiatric hospitals. Patients had at least three Dutch-born Caucasian grandparents. These findings also support the hypothesis that deficit schizophrenia is a separate disease within the schizophrenia syndrome.
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We have defined the deficit syndrome as a disease entity characterized by the presence of primary enduring negative symptoms. A focus on primary negative symptoms demonstrates that deficit and nondeficit schizophrenia subgroups differ on clinical features, associated neuroimaging findings, neuropsychological and neurological measures, pattern of risk factors, and pharmacological response …

Amelioration of deficit syndrome of schizophrenia by norepinephrine reuptake inhibitor Saeed Shoja Shafti, Mohammad Sadeghe Jafarabad, and Reza Azizi Therapeutic Advances in Psychopharmacology 2015 5 : 5 , 263-270 The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of the deficit syndrome (DS). 2 Studies comparing differences between a DS group and a non-deficit group have contributed to the hypothesis that deficit schizophrenia could be a separate disease. 7,8,9,10 However, despite evidence suggesting Given that schizophrenia is a heterogeneous disorder, 16 – 19 it is unsurprising that disputes regarding its subtyping continue, although the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition has abandoned the use of subtypes to classify the disorder. 19 Since Carpenter’s description of deficit schizophrenia (DS) syndrome was first published, 20 studies have supported The deficit syndrome is diagnosed by using longitudinally based criteria. To make a diagnosis, at least two of the following negative symptoms must be rated as primary and stable: restricted affect, diminished emotional range, poverty of speech, curbing of interests, diminished sense of purpose, and diminished social drive.